Vitamin B12 and folate are necessary for normal red blood cell formation, tissue and cellular repair, homocysteine metabolism, and DNA synthesis.* A vitamin B12 and/or folate deficiency may indicate a chronic shortage of one or both of these vitamins. Vitamin B12 deficiency can manifest in varying degrees of mental changes such as confusion and irritability.* Certain prescription medications (for seizures, diabetes, arthritis, or cancer) can result in deficiencies of these important vitamins. Incidence of vitamin B12 and/or folate deficiency is high among the elderly. Pregnant women require increased amounts of folate for proper fetal development.* Women with a folate deficiency prior to pregnancy can expect the deficiency to be intensified during gestation.

Thorne's B-Complex #12 supplies 300 mcg of adenosylcobalamin, 300 mcg of methylcobalamin, as well as 200 mcg of folinic acid, 200 mcg 5-MTHF (both active forms of folate), and the bioactive forms of the other B vitamins in each capsule to ensure you get the most bioavailable B-complex available.* B Complex #12 also consists of a group of eight water-soluble compounds: thiamin (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), pantothenic acid (vitamin B5), pyridoxine (vitamin B6), cobalamin (vitamin B12), folate, and biotin. Although each B vitamin is chemically distinct, they often work together in various biochemical functions throughout the body – from cellular energy production, to healthy red-blood-cell formation, to healthy neurological function.* Most B vitamins, with the exception of vitamin B12, are not stored in the body; consequently, they must be acquired daily from the diet in order to maintain optimal health.* Supplementing with active B vitamins is extremely important to everyone, especially individuals who may not be able to convert non-active vitamins to their active forms in the liver because of compromised liver function, poorly functioning enzymes, digestive disturbances, or age.* Dietary supplements containing these active cofactors have enhanced bioavailability, ensuring the body gets the nutrients it needs.*