This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
Iodine may occasionally cause an allergic reaction in some individuals.
If pregnant, consult your health-care practitioner before using this product.
As vitamin K interferes with the effect of anticoagulant drugs (like Coumadin), the concurrent use of these agents should be avoided.
Folinic acid and 5-methyl-tetrahydrofolate supplementation is not recommended concurrently with methotrexate cancer therapy, as they can interfere with methotrexate's anti-neoplastic activity; however, these folate sources have not been shown to interfere with the anti-inflammatory activity of methotrexate.
An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.
Curcumin has been shown to reduce the therapeutic efficacy of cyclophosphamide (Cytoxan) in animal studies.
In vitro research reveals curcumin decreased camptothecin-induced death of cultured breast cancer cells.
Curcumin might also interfere with the absorption and efficacy of the chemotherapy drug irinotecan, used to treat colon cancer.
The concurrent use of curcumin with these agents should be avoided.